Bacterial infections in the uterus can cause reduced fertility in the mare. Bacteria gain access to the uterus through the cervix, due to poor conformation or during breeding or foaling. Healthy young mares clear bacteria rapidly. In mares with compromised uterine defense mechanisms bacteria can establish an infection in the uterus. If the infection is unnoticed or left untreated, the infection may become chronic. The most commonly isolated bacteria from such conditions are Streptococcus equi subspecies zooepidemicus (Strep. zoo). In the chronically infected mare Strep. zoo can establish an infection deep within the uterine lining (endometrium). Strep zoo appear to lower its metabolic rate during chronic infection, thus complicating diagnostics and antimicrobial treatment dependent of active bacterial growth.
bActivate is a growth medium capable of reactivating dormant streptococcal infections in the uterus of broodmares. Re-activation enables diagnostics, treatment and subsequent breeding. bActivate has been tested and found highly successful by the veterinarians of Hagyard Equine Medical Institute.
Bacterial culture, activation and standard endometritis treatment should be conducted when the mare is in estrus, activation ideally taking place in early estrus (moderate uterine edema, largest follicle 25-30 mm) to allow as much of the treatment during estrus as possible.
The following steps should be included:
1.Obtain a pre-activation uterine culture sample. We recommend that the sample be obtained using either a biopsy or a low volume lavage to improve diagnostic sensitivity and specificity
2.Thaw and shake the vial to mix the activating compound before use.
3.Instill bActivate (10 ml) in the uterus of the mare using an insemination pipette and standard insemination technique.
4.Obtain a post-activation uterine culture sample 24 hours after instillation of bActivate.
5.Begin appropriate antimicrobial therapy (uterine and systemic antibiotics) based on the results of the post-activation culture sample.
bActivate can only be purchased by veterinarians. Please call the Hagyard Pharmacy to place an order (859) 281-9511.
For more information and research visit bactivate.eu.