Ciclesonide (Alvesco)

Inhaled corticosteroid (ciclesonide) for equine asthma (RAO/heaves) and inflammatory airway disease via metered-dose inhaler. Inhaled corticosteroid (ciclesonide). Prodrug activated by esterases in the lung to des-ciclesonide (active). Mechanism: binds glucocorticoid receptors → inhibits phospholipase A2 (via annexin-1), reducing arachidonic acid release and downstream prostaglandin/leukotriene production. High first-pass metabolism reduces systemic effects. Delivered via proprietary equine inhaler device. Key information Ciclesonide inhaled corticosteroid. Store at room temperature. Shake well. For equine asthma — not for acute bronchospasm. Use spacer device. Systemic absorption minimal but possible.

Inhaled: use only with the Aservo EquiHaler (equine-specific metered-dose inhaler device). Hold device over nostril; administer prescribed puffs during inspiration. Store at room temperature; protect from light. Prime inhaler per manufacturer instructions if not used recently. Do not puncture canister. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Inhaled corticosteroid: minimal systemic effects at labeled doses. Local: oral/pharyngeal candidiasis (if deposited without inhaler spacer). Adrenal suppression possible with prolonged high-dose use. Horses: coughing at time of administration.

For animals Inhaled corticosteroid — monitor for adrenal suppression with prolonged high-dose use (ACTH stimulation test). Use only with appropriate equine inhaler device. Not a bronchodilator — should not be used for acute bronchospasm. For people handling this medication Wash hands thoroughly with soap and water after handling. Inhaled corticosteroid — avoid breathing aerosol spray. Wash hands after attaching/detaching inhaler. Keep out of reach of children.

Contact your veterinarian. Excessive inhalation may cause adrenal suppression and respiratory signs.