Amiglyde-V

Serious gram-negative bacterial infections in horses and small animals including septicemia, respiratory, urinary tract, and wound infections. Aminoglycoside antibiotic (amikacin sulfate). Mechanism: irreversibly binds to 30S ribosomal subunit, causing misreading of mRNA and inhibiting bacterial protein synthesis (bactericidal). Active against aerobic gram-negative bacteria. Concentration-dependent killing. Nephrotoxic and ototoxic with prolonged use. Key information Amikacin sulfate intrauterine preparation. Refrigerate. Sterile intrauterine infusion only. Culture before treatment. Use aseptic technique. Nephrotoxic if systemic absorption occurs.

IM injection: administer deep IM into a large muscle mass. IV: dilute in 0.9% NaCl or D5W; infuse over 30–60 min. Intrauterine (mares): dilute to appropriate volume in sterile saline; infuse using aseptic technique. Once-daily dosing preferred. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Nephrotoxicity: acute tubular necrosis (dose-dependent; potentiated by dehydration, pre-existing renal disease). Ototoxicity: cochlear and vestibular damage with prolonged use. Neuromuscular blockade (potentiates non-depolarizing muscle relaxants). Monitor BUN, creatinine, and urinalysis closely.

For animals Aminoglycoside — high nephrotoxicity and ototoxicity risk. Monitor renal function, hydration status, and urine output. Ensure adequate hydration before and during therapy. Avoid concurrent use with other nephrotoxic drugs (NSAIDs, furosemide, amphotericin B). Once-daily dosing preferred (concentration-dependent). Monitor urine sediment (casts = early nephrotoxicity). Neonates: immature renal function — use extreme caution. Not approved for use in food-producing animals. For people handling this medication Injectable — administered by veterinary staff only. Wash hands thoroughly with soap and water after handling. If accidentally self-injected, seek emergency medical attention immediately. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Wear gloves when preparing or handling injectable solutions.

Contact your veterinarian. Intrauterine amikacin — systemic absorption with overdose causes nephrotoxicity.