Aminocaproic Acid

Antifibrinolytic for hemorrhage associated with hyperfibrinolysis in horses and dogs; perioperative hemostasis; investigational use in canine degenerative myelopathy. Antifibrinolytic agent (aminocaproic acid). Mechanism: competitively inhibits plasminogen activation, preventing plasmin formation and fibrin clot dissolution. Inhibits fibrinolysis without affecting coagulation cascade. Also investigated for neuroprotective effects via anti-apoptotic mechanisms. Key information Aminocaproic acid injectable — see aminocaproic acid entry. Refrigerate. IV infusion preferred. Monitor for thrombotic events.

IV: dilute in 0.9% NaCl or D5W; administer loading dose over 15–30 min, then maintenance CRI. Oral: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

GI: nausea, vomiting, diarrhea, abdominal cramping. Cardiovascular: hypotension (rapid IV). CNS: dizziness, agitation. Thrombotic risk (excessive inhibition of fibrinolysis) — use caution in hypercoagulable states. Myopathy with prolonged high-dose use.

For animals Avoid in pregnant animals. — antifibrinolytics may affect placental blood flow. Avoid in disseminated intravascular coagulation (DIC) or thromboembolic disorders. Use caution in cardiac and renal disease. Monitor for thrombotic complications. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian immediately. Supportive care required for overdose.