Amoxicillin/clavulanate Potass Tabs

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General Drug Information and Indications

Susceptible gram-positive and gram-negative bacterial infections (respiratory, urinary, skin, dental) in dogs, cats, and horses; amoxicillin/clavulanate extends spectrum to beta-lactamase producers. Aminopenicillin antibiotic. Mechanism: binds penicillin-binding proteins (PBPs) inhibiting bacterial cell wall peptidoglycan cross-linking (bactericidal). Acid-stable; good oral bioavailability. With clavulanate: extended spectrum against beta-lactamase-producing organisms. Time-dependent killing. Key information Store suspension in refrigerator; discard after 14 days. Shake well before use. Do not use in rabbits, guinea pigs, hamsters, or other hindgut fermenters — fatal enterocolitis. Cross-reactive with penicillin allergy. Short post-antibiotic effect — strict dosing intervals important.

How to Give this Medication

Oral: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Tablets may be crushed. Suspension: Shake well before each use. Store refrigerated (2–8°C); do not freeze. Injectable suspension: Administer IM only — never IV. shake well before use. Complete full course — do not stop early. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. It is important to complete the full antibiotic course even if your pet seems better.

Side Effects

GI: diarrhea, vomiting, anorexia. Hypersensitivity: urticaria, pruritus, angioedema, anaphylaxis (rare). Superinfection. Small mammals (rabbits, guinea pigs, hamsters): potentially fatal Clostridium-associated enterocolitis — contraindicated.

Precautions

For animals Contraindicated in patients with known beta-lactam hypersensitivity. Small herbivores: CONTRAINDICATED — fatal Clostridium-associated enterocolitis. Confirm susceptibility; penicillinase-sensitive. Time-dependent killing — maintain dosing schedule. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Penicillin-class — inform your doctor if you have penicillin allergy. Wash hands thoroughly with soap and water after handling. after handling.

Overdose

Contact your veterinarian. Amoxicillin overdose typically causes GI signs (vomiting, diarrhea) and is rarely life-threatening. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.

Amoxicillin/clavulanate Potass Tabs dosage forms

ProductStrengthFormSizeType
AMOXICILLIN AND CLAVULANATE POTASSIUM 62.5 MG TABLET62.5 MGTablet—Commercial
AMOXICILLIN/CLAVULANATE POTASS TABS - 125MG125 MGTablet1Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual – Penicillins Use in Animals (https://www.merckvetmanual.com/pharmacology/antibacterial-agents/use-of-penicillins-in-animals); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)