Anased Inj (xylazine)

Alpha-2 agonist sedation, analgesia, and preanesthetic medication in horses, cattle, dogs, and cats; chemical restraint; colic analgesia in horses; emesis in cats. Alpha-2 adrenergic agonist (xylazine HCl). Mechanism: stimulates presynaptic and postsynaptic alpha-2 receptors in the CNS → decreased norepinephrine release → sedation, analgesia, and muscle relaxation. Produces dose-dependent cardiovascular depression (bradycardia, initial hypertension then hypotension). Reversible with atipamezole (dogs/cats) or yohimbine. Key information DEA Schedule III. Alpha-2 agonist — causes profound cardiovascular depression (bradycardia, decreased cardiac output). Reversal agent: yohimbine (dogs/horses) or atipamezole (small animals). Horses: unpredictable response; standing sedation only — do not attempt lateral recumbency without support. Cattle: 10x more sensitive than horses — reduce dose significantly.

Xylazine injectable: Administer IV or IM as directed. Horses: typical IM dose for sedation; IV for more rapid and profound effect — give slowly. Cattle: IM only at 1/10th equine dose. Dogs/cats: IM or SQ. Onset: 3–5 min (IV), 10–15 min (IM). Have reversal agent (yohimbine or atipamezole) available. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Cardiovascular: bradycardia, first- and second-degree AV block, initial peripheral vasoconstriction then vasodilation, hypotension. Respiratory: decreased respiratory rate and tidal volume; horses may develop upper airway obstruction (head-down position). GI: decreased motility (risk of colic — horses; ruminant bloat — cattle). Diuresis (ADH inhibition). Sweating (horses). Hypersalivation (cattle — highly sensitive; 1/10th equine dose).

For animals See xylazine. Cattle: 10× more sensitive than horses — must use species-appropriate dose. Do not use in horses with pre-existing AV block or severe bradycardia. GI: ileus risk — do not use in patients with suspected GI obstruction. Horses: keep head elevated to maintain airway; monitor respiratory rate. Pre-anesthetic check: cardiac auscultation recommended. Reversal: yohimbine (dogs/cats); atipamezole (dogs/cats); no approved reversal in horses. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Xylazine is a potent sedative — accidental skin absorption or injection may cause drowsiness, low blood pressure, or bradycardia. If accidental human injection occurs, seek emergency medical attention immediately. Do not drive after handling. Keep out of reach of children.

This is a veterinary emergency. Overdose causes profound sedation, respiratory depression, and cardiovascular collapse. Reversal agent (yohimbine) is available and must be administered by veterinary staff immediately.