Banamine

NSAID for visceral pain (colic), musculoskeletal inflammation, fever, and endotoxemia in horses; flunixin meglumine is the most widely used equine NSAID. Non-selective COX inhibitor NSAID (flunixin meglumine). Mechanism: inhibits cyclooxygenase-1 and -2 → reduces prostaglandin (PGE2, TXA2) and thromboxane synthesis → anti-inflammatory, analgesic, and antipyretic effects. FDA-approved for equine use (IV/oral). Also antagonizes endotoxin-mediated hemodynamic effects. Aminonicotinic acid derivative. Time-dependent elimination. Key information NSAID — do NOT administer intra-arterially (fatal). Strictly IM or IV only in horses. Perivascular injection causes severe tissue necrosis — use IV catheter. FDA-approved transdermal gel available. Do not give to horses with GI disease — may mask signs of colic. Withdrawal time: 4 days (horses for slaughter). Monitor for RHC ulceration.

Horses — IV: administer slowly into jugular vein; do not give IM or SQ (severe tissue necrosis). Oral granules/paste: mix granules into feed or administer paste via dose syringe at the back of the tongue. Cattle: IV or IM as labeled. Small animals: oral liquid or tablet — Administer with food to reduce GI adverse effects. Store at room temperature; protect from light. If a dose is missed Flunixin meglumine is typically given as a single dose or short course. If a scheduled dose was missed, contact your veterinarian before giving another dose — do not increase frequency without guidance.

GI: gastric and right dorsal colonic ulceration (horses), gastric ulcers (small animals). Renal: acute tubular necrosis (dehydrated patients). Hematologic: platelet inhibition. Perivascular injection: severe tissue necrosis (horses — IV or oral only). Do not use with concurrent NSAID or corticosteroid. Hepatotoxicity (rare).

For animals IV route only in horses (IM or SQ injection causes severe tissue necrosis). Monitor for GI ulceration; use with caution in animals with GI disease. — gastric and right dorsal colonic ulceration; use GI protectants for prolonged therapy. Monitor renal function, hydration status, and urine output. — ensure adequate hydration. Do not use concurrently with other NSAIDs or corticosteroids. Foals: use with caution (immature renal function and gut microbiome). Use with caution in pregnant animals. — may prolong gestation. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. NSAIDs can be absorbed through skin. Avoid prolonged skin contact with oral paste. If accidental injection occurs (injectable form), seek medical attention — IV flunixin is a veterinary-only route. Keep out of reach of children. Contact Poison Control if ingested.

This is a serious situation. Overdose causes GI ulceration (especially right dorsal colitis in horses), kidney failure, and bleeding. Contact your veterinarian or emergency clinic immediately. Do not give additional doses. Supportive care including IV fluids and GI protectants will be needed.