Betameth Dip Oin

Potent fluorinated corticosteroid (betamethasone); intra-articular injections for joint inflammation; topical use for inflammatory skin and ear conditions. Fluorinated glucocorticoid (betamethasone). Mechanism: binds intracellular glucocorticoid receptors → modulates gene transcription → inhibits phospholipase A2 (via annexin-1) → reduced arachidonic acid release → decreased prostaglandins, leukotrienes, and cytokines. Potent anti-inflammatory; minimal mineralocorticoid effect. Long-acting when given as acetate/phosphate combination depot injection. Key information Betamethasone dipropionate — topical corticosteroid. See betamethasone entry. For external use only. Systemic absorption possible with large areas or prolonged use.

Injectable depot: administer IM into large muscle mass. Intra-articular: use strict aseptic technique; aspirate joint fluid before injection if effusion present; inject into joint space. Administer IV slowly; rapid infusion may cause adverse reactions. (soluble phosphate formulation). Store at room temperature; protect from light. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Corticosteroid effects: PU/PD, polyphagia, muscle wasting, immunosuppression, delayed wound healing. Adrenal suppression (HPA axis). Laminitis (horses — with single large doses or repeated injections). GI: ulceration. Behavioral: excitability, restlessness. Intra-articular overuse: cartilage damage, septic arthritis risk.

For animals Monitor for GI ulceration; use with caution in animals with GI disease. Avoid in pregnant animals. Avoid in horses with active laminitis. Do not vaccinate during therapy. Horses: single large doses can precipitate laminitis — particularly in ponies, donkeys, and horses with insulin dysregulation/EMS. Avoid concurrent NSAIDs. Not approved for use in food-producing animals. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Corticosteroid — avoid prolonged skin contact. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Wear gloves when handling injectable forms. Intra-articular injection performed by veterinarian only.

If excessive product was applied, wash the area thoroughly with mild soap and water. Contact your veterinarian if the animal shows any signs of irritation, lethargy, tremors, or other unusual behavior. Corticosteroid systemic absorption possible with excessive topical use.