Bethanechol Chloride

Parasympathomimetic for urinary retention and detrusor atony in cats and dogs; stimulates bladder contraction; GI motility stimulation. Cholinergic agonist (muscarinic receptor agonist). Mechanism: directly stimulates muscarinic M3 receptors on smooth muscle of bladder, GI tract, and other organs → detrusor contraction, increased GI motility and secretions. Not metabolized by cholinesterases; more prolonged action than acetylcholine. Does not cross blood-brain barrier significantly. Key information Do not use in animals with GI or urinary obstruction. Parasympathomimetic — may cause excessive salivation, urination, defecation. Have atropine available as antidote. Administer on empty stomach for best absorption. Do not administer IV or IM.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer on an empty stomach for optimal absorption. for best effect. SQ injection: administer SQ — do not give IV or IM. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Administer on empty stomach.

Cholinergic effects: salivation, lacrimation, vomiting, diarrhea, urinary urgency, muscle tremors, bradycardia, bronchospasm, hypotension. Serious overdose: acute cholinergic crisis. Contraindicated in GI obstruction, urethral obstruction, respiratory disease, hypotension.

For animals CONTRAINDICATED in patients with GI or urinary tract obstruction, hyperthyroidism, peptic ulcers, asthma/respiratory disease, or hypotension. Verify bladder is overdistended before use in urinary retention (rule out obstruction). Avoid in pregnant animals — stimulates uterine contractions. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Cholinergic drug — avoid ingestion (causes increased salivation, GI cramping, bronchospasm). Keep out of reach of children.

Contact your veterinarian immediately. Bethanechol overdose causes severe cholinergic signs: bradycardia, excessive salivation, GI cramps, and bronchospasm. Antidote: atropine by veterinary staff.