Biosponge

Oral di-tri-octahedral smectite adsorbent for treatment of diarrhea in horses and foals; binds bacterial toxins (C. difficile, Salmonella) to reduce intestinal inflammation. Di-tri-octahedral (DTO) smectite adsorbent. Mechanism: high surface area clay mineral with strong adsorptive capacity for bacterial toxins (Clostridioides difficile toxins A and B, Salmonella toxins, endotoxins). Coats intestinal mucosa providing a physical barrier. Not systemically absorbed. Negatively charged surface binds positively charged toxin molecules. Key information Not a drug — smectite clay adsorbent. No specific drug interactions. Safe to administer with other medications at separate times (adsorbs other drugs if given simultaneously — separate by 2 hours). Refrigerate paste form.

Oral: dissolve in water or mix into wet feed. Administer via oral syringe or mixed into palatable liquid. May be given via nasogastric tube in foals. Separate other oral medications by 2 hrs. If a dose is missed Give the missed dose as soon as you remember. If you forget a day, simply resume the normal schedule the next day. Missing an occasional dose of this supplement is unlikely to cause harm.

Mild constipation at high doses. GI: temporary change in fecal consistency. Not absorbed systemically — systemic side effects not expected. May adsorb some orally administered medications — separate administration by 2 hrs.

For animals Administer other oral medications separately (2 hrs before or after) — may adsorb co-administered drugs. Safe for foals and adult horses. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Clay adsorbent — generally safe. Wash hands thoroughly with soap and water after handling.

Overdose with this supplement is unlikely to cause serious harm at slightly elevated doses, but contact your veterinarian if a large excess was given or if your animal shows any unusual signs. Smectite clay is minimally absorbed — overdose may cause constipation.