Bravecto (feline) 2.6

Systemic ectoparasiticide (fluralaner, isoxazoline) for treatment and prevention of flea and tick infestations in dogs and cats; up to 12 weeks protection. Systemic ectoparasiticide (fluralaner). Drug class: isoxazoline. Mechanism: potent antagonist of GABA-gated chloride channels and glutamate-gated chloride channels in insects and arachnids → uncontrolled neuronal hyperexcitation → paralysis and death of parasites. High mammalian selectivity due to differences in invertebrate vs. vertebrate receptor subtypes. Lipophilic; long tissue half-life (12 weeks). Key information Store at room temperature. Dogs: oral fluralaner (systemic isoxazoline). Cats: topical. Not for use in dogs <6 months or <4.4 lbs. Isoxazoline class — use with caution in animals with neurological history. Single dose provides 12-week (oral) or 3-month (topical cat) protection.

Oral chewable tablet: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or treat. Administer every 12 weeks. Ensure the correct weight-band product is used. Store at room temperature; protect from light. If a dose is missed Bravecto provides 12-week (oral) or 3-month (topical) protection. If a dose is late by a few days, give it when remembered and resume the normal schedule.

GI: vomiting, diarrhea, decreased appetite, lethargy. CNS: tremors, ataxia (rare — at high multiples of recommended dose). Seizures reported (post-marketing); use with caution in dogs with seizure history. Generally well tolerated at labeled doses.

For animals Use with caution in dogs with known seizure history (isoxazoline class). Not labeled for puppies <6 months or <4.4 lbs. Cats: separate formulation available — do not use dog product in cats. Not approved for use in food-producing animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Isoxazoline — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children.

Contact your veterinarian. Bravecto overdose (fluralaner) may cause vomiting, tremors, and ataxia — especially in animals with neurological conditions. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.