Buscopan

Antispasmodic (hyoscine butylbromide) for smooth muscle spasm associated with gastrointestinal and urinary colic in horses. Anticholinergic antispasmodic (hyoscine butylbromide / scopolamine butylbromide). Mechanism: competitive muscarinic receptor antagonist acting predominantly on M3 receptors in GI and urogenital smooth muscle → smooth muscle relaxation and reduced spasm. Poor CNS penetration (quaternary ammonium). Rapid but short duration of action (20–30 min); transient tachycardia is expected. Key information N-butylscopolammonium bromide — spasmolytic. Short duration of action (30–45 min). May temporarily increase heart rate. Used diagnostically to relieve rectal spasm during palpation. Do not use in horses with suspected GI obstruction.

IV: administer slowly over 30–60 sec. IM: inject into large muscle mass. Horses: IV route preferred for rapid smooth-muscle relaxation. Onset: 1–3 min (IV). Duration: 15–20 min — perform examination or procedure promptly. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

Tachycardia (expected — transient, dose-dependent; up to 60 min). Dry mucous membranes. Ileus (with high doses or prolonged use). GI motility reduction. Urinary retention. Horses: post-injection tachycardia may interfere with colic assessment during that period.

For animals Do not use in horses with suspected colic caused by mechanical obstruction — may mask pain and delay surgical intervention. Transient tachycardia is expected for 15–20 minutes post-administration (do not assess heart rate for cardiac murmur during this window). Use with caution in pregnant animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Anticholinergic — avoid accidental injection or ingestion. Keep out of reach of children.

Contact your veterinarian. Buscopan overdose causes anticholinergic signs: rapid heart rate, dry mouth, and urinary retention.