Carbamazepin Tab

Anticonvulsant (carbamazepine) for management of seizures in dogs (extralabel); neuropathic pain. Iminostilbene anticonvulsant (carbamazepine). Mechanism: blocks voltage-dependent sodium channels in a use-dependent (frequency-dependent) manner → stabilizes neuronal membranes and reduces repetitive firing. Also blocks calcium channels and has adenosine receptor activity. Hepatically metabolized via CYP3A4; induces its own metabolism. Key information Anticonvulsant/sodium channel blocker. Store at room temperature. Narrow therapeutic index — monitor levels. Drug interactions — CYP inducer. Monitor CBC and hepatic function.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. to reduce GI upset. Do not crush extended-release formulations. Administer at consistent times. Therapeutic drug monitoring recommended. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

CNS: sedation, ataxia, drowsiness. GI: vomiting, diarrhea, anorexia. Hematologic: aplastic anemia, agranulocytosis (rare but serious — monitor CBC). Hepatotoxicity (monitor liver enzymes). Hyponatremia. Drug interactions: CYP3A4 inducer (reduces levels of many co-administered drugs). Skin rash.

For animals Monitor liver enzymes with prolonged use. Monitor CBC periodically with prolonged use. (aplastic anemia risk). Drug interactions: induces CYP3A4 — reduces levels of many concurrent medications. Monitor serum drug levels where possible. Avoid in pregnant animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Anticonvulsant — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Teratogenic. Store securely away from children.

Contact your veterinarian immediately. Carbamazepine overdose causes serious neurological and cardiac effects.