Carboplatin Inj

Platinum-based chemotherapy for carcinomas, osteosarcoma, and other neoplasms in dogs and cats. Platinum-based alkylating chemotherapy agent. Mechanism: forms DNA interstrand and intrastrand cross-links via platinum-DNA adducts → inhibits DNA replication and transcription → cell death (cell cycle non-specific). Less nephrotoxic than cisplatin. Myelosuppression is primary dose-limiting toxicity. Key information CYTOTOXIC — handle with chemotherapy precautions (gloves, gown, mask). Nephrotoxic and myelosuppressive. Monitor CBC/serum chemistry. Ensure hydration before and after treatment. Reconstituted solution stable 8 hours at room temp. Dispose of as hazardous waste.

IV infusion: dilute in D5W (do not use saline — precipitates); administer over 15–60 min. Use appropriate cytotoxic handling protocols (gloves, gown, eye protection). Reconstituted solution: use within 8 hrs. Pre-medicate with antiemetics. Store refrigerated (2–8°C); do not freeze. Protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Myelosuppression: neutropenia, thrombocytopenia (nadir 10–14 days — monitor CBC). GI: severe nausea, vomiting, anorexia. Nephrotoxicity (less than cisplatin but monitor renal function). Ototoxicity. Peripheral neuropathy (rare). Anaphylaxis (subsequent treatments).

For animals Monitor renal function, hydration status, and urine output. Monitor CBC periodically with prolonged use. — monitor CBC at nadir (10–14 days). Dose based on GFR in patients with renal impairment. Avoid concurrent nephrotoxic drugs. Avoid in pregnant animals. Pre-medicate with antiemetics. For people handling this medication Wear gloves when handling. CYTOTOXIC CHEMOTHERAPY. Wear gloves, gown, and eye protection when handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. — teratogenic and embryotoxic. Do not handle if pregnant or breastfeeding. Dispose of waste per cytotoxic drug protocols. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. If skin contact, wash immediately with soap and water. Contact Poison Control if ingested.

This is a veterinary emergency. Carboplatin is a cytotoxic chemotherapy agent. Overdose causes severe bone marrow suppression, kidney failure, and GI toxicity. Intensive supportive care required. Contact your veterinary oncologist immediately.