Ceftazidime Inj
General Drug Information and Indications
Third-generation cephalosporin with Pseudomonas activity; serious gram-negative infections; ophthalmic use; septicemia in foals.
Third-generation cephalosporin with Pseudomonas activity. Mechanism: binds PBPs → inhibits cell wall synthesis (bactericidal). Exceptional gram-negative coverage including Pseudomonas aeruginosa. Poor gram-positive coverage. Stable against many beta-lactamases. Used parenterally and in ophthalmic preparations.
Key information
Third-generation cephalosporin — excellent gram-negative/Pseudomonas coverage. Reconstitute with sterile water. Refrigerate reconstituted solution; use within 24 hours. IV over 30 min.
How to Give this Medication
IV: dilute in 0.9% NaCl or D5W; administer over 30 min. IM: inject deep into large muscle mass. Ophthalmic compounded solution: Instill into the conjunctival sac; avoid touching dropper tip to eye or periocular tissue. Store refrigerated (2–8°C); do not freeze. (reconstituted/compounded solution).
If a dose is missed
This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.
Side Effects
GI: diarrhea, nausea. Hypersensitivity reactions (beta-lactam class). Phlebitis (IV). CNS: seizures (high doses, renal impairment). Superinfection.
Precautions
For animals
Avoid in beta-lactam-hypersensitive patients. Reduce dose or extend interval in renal impairment. — dose-reduce in renal impairment.
For people handling this medication
Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Cephalosporin — inform your doctor if you have beta-lactam allergy. Wash hands thoroughly with soap and water after handling.
Overdose
Contact your veterinarian. Ceftazidime overdose may cause neurotoxicity (seizures) and kidney damage. Supportive care required.
Ceftazidime Inj dosage forms
| Product | Strength | Form | Size | Type |
|---|---|---|---|---|
| CEFTAZIDIME INJ 2GM (WGCritical) | 2 GM | Injectable | 1 | Commercial |
| CEFTAZIDIME INJ 2GM (Sagent) | 2 GM | Injectable | 1 | Commercial |
Sources
This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)