General Drug Information and Indications

First-generation oral cephalosporin for susceptible bacterial skin, soft tissue, and urinary tract infections in dogs, cats, and horses. First-generation oral cephalosporin. Mechanism: binds PBPs → inhibits bacterial cell wall peptidoglycan synthesis (bactericidal). Primary activity against gram-positive organisms (Staphylococcus, Streptococcus); limited gram-negative spectrum. Good oral bioavailability; renally excreted. Key information Store suspension refrigerated; discard after 14 days. Shake well. Administer with food if GI upset occurs. Avoid in animals with cephalosporin hypersensitivity. Do not use in rabbits or hindgut fermenters.

How to Give this Medication

Oral capsules or tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. to reduce GI upset. Oral suspension: Shake well before each use. Store refrigerated (2–8°C); do not freeze. Complete full prescribed course. Store at room temperature; protect from light. (tablets/capsules). If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Always complete the full antibiotic course.

Side Effects

GI: vomiting, diarrhea, anorexia (common with oral dosing). Hypersensitivity: urticaria, pruritus, anaphylaxis. Superinfection. Rarely: hepatotoxicity (with prolonged use).

Precautions

For animals Avoid in patients with known cephalosporin or penicillin hypersensitivity. {RENAL} Administer with food to reduce GI adverse effects. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Cephalosporin — inform your doctor if you have penicillin or cephalosporin allergy. Wash hands thoroughly with soap and water after handling.

Overdose

Contact your veterinarian. Overdose usually causes GI upset. Rarely serious. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.

Cephalexin Cap dosage forms

ProductStrengthFormSizeType
CEPHALEXIN CAP 250MG250 MGCapsule1Commercial
CEPHALEXIN CAP 500MG500MGCapsule—Commercial
CEPHALEXIN CAP 500MG500MGCapsule—Commercial
CEPHALEXIN CAP 500MG500MGCapsule—Commercial
CEPHALEXIN SUS 250/5ML——5MLCommercial
CEPHALEXIN SUS 250/5ML——5MLCommercial
CEPHALEXIN SUS 250/5ML——5MLCommercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)