Cerenia Tabs

Maropitant (NK1 receptor antagonist) for prevention and treatment of nausea and vomiting in dogs and cats; prevention of motion sickness; visceral pain management in horses. Neurokinin-1 (NK1) receptor antagonist / antiemetic (maropitant citrate). Mechanism: centrally acting selective NK1 receptor antagonist that blocks substance P binding in the vomiting center (nucleus tractus solitarius and emetic center). Prevents acute and delayed vomiting. Also has peripheral visceral analgesic effects via peripheral NK1 receptors. Well absorbed orally; hepatically metabolized. Key information Maropitant — NK1 receptor antagonist. Store at room temperature. Refrigerate injectable solution. Subcutaneous injection may be painful — aspirate; cold solution reduces discomfort. Dogs: approved for vomiting prevention and motion sickness. Cats: approved for vomiting. Do not use in animals <16 weeks old.

Oral tablets (dogs and cats): Administer orally. May be given with food to improve compliance and reduce GI upset. Administer on an empty stomach for optimal absorption. or with a small amount of food (dogs: 1 hr before travel for motion sickness). Injectable (SQ): administer SQ; may sting — inject slowly. IV (extra-label): dilute and infuse slowly. Refrigerate injectable solution; oral tablets at room temperature. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

GI: hypersalivation, vomiting (rare — paradoxical), lethargy, anorexia. Pain at injection site (subcutaneous). CNS: ataxia (rare, high doses). Drowsiness. Generally well tolerated.

For animals Dogs: approved for motion sickness (1 dose/day) and acute/delayed vomiting. Cats: approved for acute vomiting (not motion sickness). Avoid in patients with GI obstruction or intestinal ileus — rule out mechanical obstruction before use. Use with caution in hepatic impairment. Drug interaction: maropitant is highly protein-bound — potential for drug displacement interactions. Avoid in pregnant animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). NK1 antagonist antiemetic — Wash hands thoroughly with soap and water after handling. after handling tablets or injectable. Keep out of reach of children.

Contact your veterinarian. Maropitant overdose typically causes lethargy and mild sedation. Rarely serious. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.