Cetirizine Hcl

Second-generation antihistamine for allergic pruritus, urticaria, and atopic dermatitis in dogs; minimal sedation. Second-generation H1 antihistamine (cetirizine HCl). Mechanism: competitive inverse agonist at peripheral H1 histamine receptors → inhibits histamine-mediated pruritus, vasodilation, and increased vascular permeability. Low CNS penetration compared to first-generation antihistamines → minimal sedation. Active metabolite of hydroxyzine. Renal elimination. Key information Store at room temperature. Non-sedating antihistamine. Safe for long-term use. Renally excreted — dose adjust in renal insufficiency.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Tablets may be crushed and mixed with food. Administer with food to reduce GI adverse effects. or without food. Administer once or twice daily as directed. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

Sedation (less than first-generation antihistamines but possible). GI: vomiting, hypersalivation in some animals. Urinary retention (rare — mild anticholinergic effect). Generally well tolerated at recommended doses.

For animals Use with caution in patients with renal impairment (Reduce dose or extend interval in renal impairment.). Cats: evidence of efficacy limited; sedation variable. Generally well tolerated. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Antihistamine — may cause drowsiness in humans if accidentally ingested. Keep out of reach of children.

Contact your veterinarian. Cetirizine overdose causes sedation and anticholinergic signs. Rarely serious. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.