Cinacalcet Tab

Calcimimetic for primary hyperparathyroidism and hypercalcemia in dogs and cats. Calcimimetic agent (cinacalcet HCl). Mechanism: allosteric activator of the calcium-sensing receptor (CaSR) on parathyroid chief cells → increases receptor sensitivity to extracellular calcium → suppresses PTH secretion → reduces serum calcium. Does not affect calcium absorption or bone metabolism directly. Key information Calcimimetic — for hyperparathyroidism. Monitor calcium and PTH levels. GI side effects common — administer with food. Store at room temperature.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Do not crush or split film-coated tablets. Monitor serum calcium within 1 week of initiating or dose change. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Administer with food.

GI: nausea, vomiting, anorexia. Hypocalcemia: muscle cramps, tetany, seizures (monitor serum calcium carefully). Paresthesias. Cardiovascular: QT prolongation (rare). Adynamic bone disease with over-suppression of PTH.

For animals Monitor ionized calcium closely — risk of hypocalcemia (tetany, seizures). Monitor serum calcium, phosphorus, and PTH levels regularly. Dose-adjust based on response. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Calcimimetic — keep away from children (dangerous if ingested — hypocalcemia). Store securely.

Contact your veterinarian. Cinacalcet overdose causes severe hypocalcemia: muscle spasms, seizures, and cardiac arrhythmias. Emergency calcium supplementation may be required.