Clarithromyc Tab

Macrolide for Rhodococcus equi in foals (extralabel), respiratory infections, and Helicobacter/Mycobacterium infections. Macrolide antibiotic (clarithromycin). Mechanism: binds 50S ribosomal subunit (23S rRNA) → inhibits bacterial protein synthesis and translocation. Excellent intracellular tissue penetration for treatment of Rhodococcus equi and other intracellular pathogens. Hepatically metabolized; active 14-OH clarithromycin metabolite. Numerous CYP3A4 drug interactions. Key information Clarithromycin — see clarithromycin entry. Administer with food. Drug interactions (CYP3A4 inhibitor). Foals: combine with rifampin for Rhodococcus equi.

Oral tablets (foals): administer orally via syringe or mixed into milk replacer. Suspension (compounded): Shake well before each use. Store refrigerated (2–8°C); do not freeze. Monitor foal's body temperature daily throughout treatment. Store at room temperature; protect from light. (tablets). If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Administer with food. Complete the full course.

GI: diarrhea, vomiting, abdominal cramps. QT prolongation, arrhythmias (rare). Hepatotoxicity. Foals: hyperthermia and severe adverse respiratory effects (acute-onset pulmonary disease reported with macrolide/rifampin combination — critical side effect; monitor temperature). Numerous CYP3A4 drug interactions.

For animals Foals: hyperthermia risk — monitor temperature daily; always use in combination (with rifampin) for Rhodococcus equi. Mares nursing treated foals: must be kept separate — severe diarrhea risk from macrolide exposure via mammary secretions. QT prolongation — avoid in patients with cardiac disease or concurrent QT-prolonging drugs. Monitor liver enzymes with prolonged use. Numerous CYP3A4 drug interactions. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Macrolide — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Teratogenic in animals — avoid handling if pregnant.

Contact your veterinarian. Clarithromycin overdose causes GI signs and possible cardiac arrhythmias.