Clavamox

Susceptible bacterial infections (respiratory, urinary, skin, soft tissue, dental) in dogs, cats, and horses; amox/clav extends spectrum to beta-lactamase-producing organisms. Aminopenicillin antibiotic (amoxicillin ± clavulanate). Mechanism: inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), preventing peptidoglycan cross-linking (bactericidal). Amoxicillin: acid-stable, orally bioavailable. Clavulanate: beta-lactamase inhibitor extending spectrum to resistant organisms (Staph, E. coli, Pasteurella). Key information Refrigerate reconstituted suspension; discard after 10 days. Shake well. Do not use in rabbits or hindgut fermenters. Short shelf life once reconstituted. Administer with food to reduce GI effects.

Oral tablets/chewables: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. (especially amoxicillin-clavulanate — food reduces GI effects). Oral suspension: Shake well before each use. Store refrigerated (2–8°C); do not freeze. Injectable (amoxicillin trihydrate suspension): Administer IM only — never IV. — shake well, inject deep IM. Complete full course. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Always complete the full course of antibiotics.

GI: diarrhea, vomiting, anorexia (particularly in cats). Hypersensitivity reactions: urticaria, pruritus, angioedema, anaphylaxis. Superinfection with resistant organisms. Clavulanate component increases GI adverse effects vs. amoxicillin alone.

For animals Penicillinase-sensitive — confirm susceptibility before use in infections likely involving beta-lactamase-producing organisms. With clavulanate: extended spectrum but increased GI adverse effects. Do not use in patients with known beta-lactam hypersensitivity. Small herbivores (rabbits, guinea pigs, hamsters): contraindicated — fatal Clostridium-associated enterocolitis. Time-dependent killing — dosing interval critical. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Penicillin-class antibiotic — inform your doctor if you have penicillin allergy. Wash hands after administering to pets.

Contact your veterinarian. GI signs (vomiting, diarrhea) are most likely. Supportive care if needed.