Cromolyn Sodium

Mast cell stabilizer for prevention of allergic airway disease in horses and small animals; via nebulization or inhalation. Mast cell stabilizer (cromolyn sodium). Mechanism: prevents antigen-induced mast cell degranulation, inhibiting release of histamine, leukotrienes, and other inflammatory mediators. Exact mechanism uncertain — may block chloride channels and prevent calcium influx into mast cells. Prophylactic only; no effect on acute bronchoconstriction. Key information Mast cell stabilizer. For nebulization use. Does not provide immediate relief — preventive only. Store at room temperature; protect from light. Consistent administration required.

Nebulized: dilute 4% solution in sterile saline; nebulize over 10–15 min q6–8h. Must be used prophylactically — not effective for acute episodes. Ophthalmic solution: Instill into the conjunctival sac; avoid touching dropper tip to eye or periocular tissue. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

Topical: transient nasal/ocular stinging/burning. Bronchospasm (paradoxical — rare with nebulized form). Systemic effects minimal (poorly absorbed). Coughing with inhalation.

For animals Prophylactic only — not effective for acute bronchospasm. Allow 4–6 weeks for full effect. Do not discontinue abruptly. Ensure adequate nebulization technique. For people handling this medication Wash hands thoroughly with soap and water after handling. Mast cell stabilizer — generally safe to handle. Avoid inhaling nebulized aerosol. Keep out of reach of children.

Contact your veterinarian. Cromolyn overdose typically causes mild bronchospasm and GI signs. Low systemic absorption.