Cytopoint

Caninized monoclonal antibody (lokivetmab) targeting IL-31 for atopic dermatitis and pruritus in dogs; monthly injection. Monoclonal antibody anti-cytokine therapy (lokivetmab). Mechanism: canine-derived monoclonal antibody that specifically binds and neutralizes interleukin-31 (IL-31) — a key pruritogenic cytokine signaling through JAK1/JAK3 pathway. By blocking IL-31, interrupts itch signal transmission. Monthly subcutaneous injection; sustained-release pharmacokinetics. Key information Monoclonal antibody (lokivetmab). Subcutaneous injection only. Refrigerate; do not freeze. Single-use vial. Allow to warm to room temperature before administration. Dogs only. Once monthly dosing.

SQ injection: administer SQ, typically in the dorsal neck or scruff region. Administer once monthly. Ensure correct dose is drawn based on body weight. Store refrigerated (2–8°C); do not freeze. Bring to room temperature before injection (15–20 min). Single-use vial. If a dose is missed This product is given as a single dose or as part of a defined protocol. Contact your veterinarian if a scheduled administration was missed. Cytopoint is a monthly injection — contact your veterinarian to reschedule.

Injection site reactions (mild, transient — most common adverse effect). GI: vomiting, diarrhea (uncommon). Upper respiratory signs (uncommon). Lethargy (rare). Generally very well tolerated as a biologic therapy. Anaphylaxis (very rare).

For animals Dogs only — not for use in cats (feline formulation is Solensia/frunevetmab). Do not administer concurrently with other monoclonal antibody therapies without veterinary supervision. Post-marketing reports of neurological signs (ataxia, paresis) — monitor closely, especially in neurologically predisposed patients. Not approved for use in food-producing animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Monoclonal antibody — Injectable — administered by veterinary staff only. Wash hands thoroughly with soap and water after handling. If accidentally self-injected, seek emergency medical attention immediately. Standard injection safety. Keep out of reach of children.

Contact your veterinarian. Monoclonal antibody — overdose with a single extra dose is unlikely to cause serious harm, but contact your vet for guidance.