Desmopressin Tab

Synthetic ADH analogue for diabetes insipidus in dogs and cats; management of von Willebrand disease before surgery. Synthetic vasopressin (ADH) analogue (DDAVP — 1-desamino-8-D-arginine vasopressin). Mechanism: selectively activates V2 vasopressin receptors in renal collecting ducts → increases aquaporin-2 water channels → enhanced water reabsorption → reduced urine volume (antidiuretic effect). Also stimulates von Willebrand factor and Factor VIII release from endothelial cells (hemostatic effect at higher doses). Key information ADH analogue. Store at room temperature. Intranasal or oral routes. Avoid in animals with hyponatremia — dilutional risk. Monitor water intake and urine output.

Ophthalmic solution (used extra-label for hemostasis): apply to conjunctival sac as directed. Intranasal drops: instill prescribed number of drops into nostril. SQ injection: administer SQ. Restrict water access during monitoring. Store refrigerated (2–8°C); do not freeze. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose.

Hyponatremia/water intoxication (excessive water retention — monitor electrolytes). GI: nausea, abdominal cramping. Cardiovascular: hypertension, tachycardia (high doses). Headache. Facial flushing. Platelet aggregation effects (at IV doses for hemostasis).

For animals Monitor sodium and serum osmolality — risk of hyponatremia and water intoxication. Restrict water access during monitoring. Reduce dose or extend interval in renal impairment. Avoid in patients with polyuric conditions where cause is unknown before diagnosis. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Synthetic ADH — avoid ingestion (causes water retention). Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Keep out of reach of children.

Contact your veterinarian. Desmopressin overdose causes water retention, low sodium (hyponatremia), and seizures in severe cases. Monitor water intake and urination.