Dexmedetomidine Hcl Inj

Highly selective alpha-2 agonist for sedation, analgesia, and muscle relaxation in dogs and cats; preanesthetic; reversed with atipamezole. Highly selective alpha-2 adrenergic agonist (dexmedetomidine HCl). Mechanism: full agonist at alpha-2A, alpha-2B, alpha-2C receptors → presynaptic and postsynaptic CNS norepinephrine suppression → dose-dependent sedation, analgesia, and anxiolysis; also causes peripheral vasoconstriction (initial) and bradycardia. ~8× more alpha-2 selective than xylazine. Reversible with atipamezole. Key information Alpha-2 agonist. Reversal: atipamezole (Antisedan). Marked cardiovascular depression — use in stable patients only. Profound sedation and analgesia. Causes vomiting in cats (useful diagnostic tool). Store at room temperature.

Injectable: IM, IV (slowly), or as CRI. IV: dilute in 0.9% NaCl; Administer IV slowly; rapid infusion may cause adverse reactions. over 5–10 min. IM: inject into large muscle mass. Buccal gel (Sileo): apply measured dose between cheek and gum using calibrated syringe — do not allow dog to drink or eat for 30 min after. Reversal: atipamezole IM. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Cardiovascular: bradycardia, second-degree AV block, peripheral vasoconstriction (biphasic — initial hypertension then hypotension). Respiratory: reduced rate and depth. GI: decreased motility. Vomiting (cats — common). Diuresis. Hypothermia. Pale mucous membranes (vasoconstriction). Ataxia. Pain at IM injection site.

For animals Monitor heart rate and rhythm continuously. Reversed with atipamezole (IM). Horses: use with caution — not approved; medetomidine or xylazine are the licensed equine alpha-2 agonists. Cats: vomiting is common post-administration — have patient positioned appropriately. Geriatric or debilitated patients: use reduced doses. Use with caution in pregnant animals. For people handling this medication Wear gloves when handling. Potent alpha-2 agonist — serious sedative. Avoid skin contact and accidental injection. Even small amounts can cause dangerous sedation and cardiovascular depression in humans. If accidentally injected, seek emergency medical attention immediately. Keep out of reach of children.

This is a veterinary emergency. Overdose causes severe sedation and cardiovascular depression. Reversal with atipamezole (Antisedan) by veterinary staff is required immediately.