Dmso/dexamethasone

Topical/systemic vehicle for drug penetration enhancement in horses; anti-inflammatory and antioxidant properties; treatment of cerebral edema. Dimethyl sulfoxide — organosulfur solvent and vehicle. Mechanism: penetrates biological membranes (carries other drugs transdermally); free radical scavenger; anti-inflammatory via inhibition of prostaglandin synthesis; reduces cerebral edema via osmotic mechanism; modulates ion channels. Also used as a cryoprotectant. Distinctive garlic/oyster odor after application. Key information HUMAN SAFETY: DMSO carries dexamethasone through skin — wear chemical-resistant gloves. Avoid all skin contact. Corticosteroid systemic effects apply.

Topical: apply to clean, dry skin using gloved hands (chemical-resistant gloves). Rub gently into affected area. Ensure the animal's skin is free of other topical substances before applying (DMSO carries co-applied substances dermally). IV (equine, diluted): dilute to ≤10% in sterile saline; infuse slowly. Store at room temperature; protect from light. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Strong garlic/oyster odor (client warning — transferred to breath/urine). Skin: erythema, pruritis, urticaria at application site. GI: nausea, vomiting if ingested. Potentiation of other topically co-applied drugs (both desired and toxic effects). Hemolysis with concentrated preparations applied to large wounds. Avoid eye contact.

For animals Do not apply to skin that has been in contact with other topical substances — DMSO carries co-applied substances dermally and can deliver unintended toxic agents systemically. Use diluted formulations (≤90%) to reduce skin irritation. Avoid use near open wounds without understanding what other agents may be present. For people handling this medication Wear gloves when handling. DMSO enhances dexamethasone skin penetration — wear chemical-resistant gloves at all times. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Significant systemic corticosteroid absorption possible. Wash hands thoroughly with soap and water after handling. immediately after contact.

Contact your veterinarian. DMSO is a carrier — overdose effects depend on co-administered drugs. DMSO itself causes garlic odor and mild local irritation. The real risk is from drugs dissolved in DMSO.