Dmso/isoflupredone Acetate

Compounded topical preparation of isoflupredone (corticosteroid) in DMSO for enhanced anti-inflammatory penetration; treatment of soft tissue and joint inflammation in horses. Compounded topical leg paint: DMSO (solvent-penetration enhancer) + isoflupredone acetate (fluorinated corticosteroid — potent glucocorticoid receptor agonist). Enhanced transdermal corticosteroid delivery for soft tissue and periarticular inflammation in horses. Key information HUMAN SAFETY: DMSO carrier — wear chemical-resistant gloves. Isoflupredone has potent mineralocorticoid effects. Monitor sodium/potassium.

Topical: apply to clean, dry skin using gloved hands (chemical-resistant gloves). Rub gently into affected area. Ensure the animal's skin is free of other topical substances before applying (DMSO carries co-applied substances dermally). IV (equine, diluted): dilute to ≤10% in sterile saline; infuse slowly. Store at room temperature; protect from light. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

DMSO: garlic odor, enhanced dermal corticosteroid absorption — significant systemic corticosteroid effects possible. Isoflupredone: HPA suppression, hypokalemia, laminitis risk, immunosuppression. Monitor for systemic corticosteroid effects with large-area topical use.

For animals Do not apply to skin that has been in contact with other topical substances — DMSO carries co-applied substances dermally and can deliver unintended toxic agents systemically. Use diluted formulations (≤90%) to reduce skin irritation. Avoid use near open wounds without understanding what other agents may be present. For people handling this medication Wear gloves when handling. DMSO significantly enhances skin penetration of isoflupredone. Wear chemical-resistant gloves. Even brief skin contact can result in significant systemic corticosteroid absorption. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Wash hands thoroughly with soap and water after handling. immediately if skin contact.

Contact your veterinarian. DMSO is a carrier — overdose effects depend on co-administered drugs. DMSO itself causes garlic odor and mild local irritation. The real risk is from drugs dissolved in DMSO.