Dopram

Respiratory stimulant (doxapram) for neonatal respiratory depression at birth; reversal of anesthetic-induced respiratory depression. Respiratory stimulant (doxapram HCl). Mechanism: stimulates peripheral carotid body chemoreceptors → increases respiratory drive and tidal volume; also direct CNS respiratory center stimulation at higher doses. Rapid onset (within 2 min IV). Short duration; may require repeat dosing. Also causes CNS excitation and cardiovascular stimulation. Key information Doxapram — respiratory stimulant. IV only. Use in neonates for respiratory depression. Short duration of action. Do not use in animals with seizure disorders or hypertension. Monitor respiratory rate carefully.

IV: administer as rapid IV bolus for respiratory stimulation; may repeat every 5 min. SQ: for neonatal resuscitation — administer SQ or under tongue. Neonatal foals: a few drops under the tongue or SQ. Have supplemental oxygen available. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

CNS: seizures, tremors (high doses or rapid IV). Cardiovascular: tachycardia, hypertension, arrhythmias. Respiratory: paradoxical apnea with excessive stimulation. Neonates: metabolic acidosis, hypoglycemia with high doses. Very short duration — may require repeat dosing.

For animals Short-acting — may require repeat dosing. Avoid in neonates with suspected CNS depression from other causes (e.g., CNS malformations). Contraindicated in patients with seizure disorders. Not approved for use in food-producing animals. For people handling this medication Wear gloves when handling. Respiratory stimulant — avoid skin contact with injectable form. Injectable — administered by veterinary staff only. Wash hands thoroughly with soap and water after handling. If accidentally self-injected, seek emergency medical attention immediately. Keep out of reach of children.

Contact your veterinarian. Doxapram overdose causes seizures, tachycardia, and hypertension.