Dormosedan

Alpha-2 agonist (detomidine) for sedation and analgesia in horses; standing sedation for minor procedures; injectable and oral gel formulations. Alpha-2 adrenergic agonist (detomidine HCl). Mechanism: potent and highly selective alpha-2 agonist → inhibits presynaptic norepinephrine release and postsynaptic adrenergic activity in the CNS → dose-dependent sedation, analgesia, and muscle relaxation. ~10× more potent than xylazine in horses. Available as injectable and oral gel formulations. No reversal agent approved in horses. Key information See Detomidine entry. Gel formulation: sublingual/oral mucosal — do not allow eating or drinking for 30 min after dosing. DEA Schedule III. Reversal: atipamezole.

Injectable: administer IV or IM (horses). IV onset: 2–5 min; IM onset: 20–40 min. Oral gel (Dormosedan Gel): apply measured dose to the space between the cheek and gum using the calibrated syringe; do not allow horse to eat or drink for 30 min. Must be held 30–40 min for full effect — do not re-dose prematurely. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Cardiovascular: bradycardia, AV block, initial peripheral vasoconstriction then vasodilation/hypotension. Respiratory: reduced rate and tidal volume. GI: decreased motility (ileus, colic risk — monitor horses). Diuresis. Sweating (horses). Ataxia. Penile prolapse (stallions). No approved reversal agent for horses.

For animals No approved reversal agent for horses. Monitor cardiac and respiratory function. Horses: keep head elevated; monitor for GI ileus. Oral gel: onset 40 min — do not re-dose prematurely. Stallions: penile prolapse risk. For people handling this medication Wear gloves when handling. Potent alpha-2 agonist sedative — avoid skin contact, especially with oral gel (highly concentrated). If skin contact occurs, wash immediately. If accidentally injected or ingested, seek emergency medical attention immediately. Do not drive or operate machinery after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Keep out of reach of children.

This is a veterinary emergency. Overdose causes severe cardiovascular and respiratory depression. Reversal agent (atipamezole) must be administered immediately by veterinary staff.