Dorzol/timol Sol

Dorzolamide/timolol combination ophthalmic drops for glaucoma management; dual mechanism IOP reduction. Topical ophthalmic combination: dorzolamide (carbonic anhydrase inhibitor) + timolol (beta-blocker). Dual mechanism IOP reduction: dorzolamide reduces aqueous humor production (CA inhibition); timolol reduces aqueous humor production and increases outflow (beta-2 blockade). Synergistic effect; convenient single-formulation dosing. Key information Combined dorzolamide/timolol ophthalmic. Systemic beta-blocker absorption possible (timolol) — caution in animals with heart disease. Carbonic anhydrase inhibitor component — avoid in sulfa-sensitive animals. Contains benzalkonium chloride.

Ophthalmic solution (dorzolamide/timolol): Instill into the conjunctival sac; avoid touching dropper tip to eye or periocular tissue. Instill 1 drop into affected eye(s) q12h. Use punctal occlusion after instillation. Store at room temperature; protect from light. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Combined effects of dorzolamide + timolol. Ocular stinging, burning, bitter taste, superficial punctate keratopathy. Timolol systemic absorption: bradycardia, bronchospasm, hypotension. Administer punctal occlusion to reduce systemic absorption.

For animals Combination dorzolamide/timolol — see individual precautions. Timolol systemic absorption: use with caution in patients with bronchospasm, bradycardia, or AV block. Monitor IOP. For people handling this medication Wash hands thoroughly with soap and water after handling. Ophthalmic combination — avoid human eye contact. Timolol component: systemic absorption may affect people with heart or lung disease — use punctal pressure when applying. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention.

Contact your veterinarian if systemic signs appear (bradycardia from timolol component). Flush eye with clean water if excessive product instilled.