Doxycycline Hyclate/enrofloxacin

Compounded combination of doxycycline (tetracycline) and enrofloxacin (fluoroquinolone) for broad-spectrum treatment of bacterial infections including intracellular and gram-negative organisms. Tetracycline antibiotic. Mechanism: reversibly binds 30S ribosomal subunit → inhibits bacterial protein synthesis (bacteriostatic). Lipophilic; excellent tissue and intracellular penetration for tick-borne and intracellular pathogens. Fecal elimination; can be used with renal dysfunction. Do not combine with dairy or multivalent cations (chelation reduces absorption). Key information Combination antibiotic — broad-spectrum. Administer with food and water (esophageal ulceration risk from doxycycline). Do not use in growing animals (enrofloxacin). Monitor for GI and photosensitivity effects.

Oral tablets/capsules: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Follow immediately with water. Cats: after pilling, follow with 6 mL of water via syringe and observe swallowing — esophageal stricture risk. Suspension: Shake well before each use. IV: dilute and infuse over 1 hr — do not rapid infuse. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Always give with food and water, and complete the full course of antibiotics.

GI: esophageal stricture (cats — critical: always give with water/food and ensure swallowing; consider doxycycline hyclate tablets or pilling technique), vomiting, anorexia. Hepatotoxicity (rare). Photosensitivity. Tooth/bone developmental effects in young animals. Superinfection.

For animals Cats: esophageal stricture risk — always give with water and food; use hyclate tablets when possible. Use with caution in pregnant animals. Avoid in neonates and young animals (bone/tooth discoloration). Avoid concurrent antacids, dairy, and multivalent cations. Monitor liver enzymes with prolonged use. with prolonged use. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Tetracycline — Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Avoid during pregnancy. Photosensitivity. Wash hands thoroughly with soap and water after handling. after handling.

Contact your veterinarian immediately. Overdose causes GI signs, liver toxicity (at very high doses), and esophageal damage. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.