Enalapril Tab

ACE inhibitor for congestive heart failure, systemic hypertension, and chronic renal disease in dogs and cats. ACE inhibitor (enalapril maleate). Mechanism: prodrug — esterified to active enalaprilat in the liver → inhibits angiotensin-converting enzyme → reduces angiotensin II production → vasodilation, reduced aldosterone secretion, decreased sympathetic tone. Reduces cardiac preload and afterload; protective in heart failure and CKD. Renally excreted. Key information ACE inhibitor. Monitor renal function and potassium after initiation. Avoid in pregnant animals (fetotoxic). First-dose hypotension — start at low end of dose range. Give consistently — food may slightly reduce absorption. Store at room temperature.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or without. Tablets may be crushed and mixed into food. Administer at consistent times. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose.

Hypotension (especially first-dose effect with concurrent diuretics). Azotemia: pre-renal or intra-renal (RAAS blockade in patients with renal artery stenosis). Hyperkalemia. GI: anorexia, vomiting. Dry cough (less common in animals). Angioedema (rare).

For animals Monitor renal function and potassium within 1–2 weeks of initiating therapy. Avoid in patients with bilateral renal artery stenosis or severe hypotension. Avoid in pregnant animals. Do not use with potassium-sparing diuretics (hyperkalemia). Reduce dose or extend interval in renal impairment. — reduce dose in renal impairment. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). ACE inhibitor — keep away from children. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Contraindicated in human pregnancy (causes fetal harm). Store securely.

Contact your veterinarian. ACE inhibitor overdose causes severe low blood pressure. Signs include weakness, collapse, and pale gums. IV fluid support required.