Equidone Gel 25cc

Domperidone

General Drug Information and Indications

Domperidone for equine fescue-associated agalactia; stimulates prolactin release and milk production in fescue-affected mares. Dopamine D2 receptor antagonist (domperidone). Mechanism: blocks D2 receptors in anterior pituitary lactotrophs → disinhibits prolactin secretion → stimulates mammary gland development and milk production. Also acts on D2 receptors in GI tract → prokinetic effects. Used for fescue toxicosis-induced agalactia in mares. Key information Domperidone for horses — fescue toxicosis/agalactia. Store at room temperature. Once daily dosing. May cause galactorrhea.

How to Give this Medication

Oral solution: Administer orally via dose syringe placed at the back of the tongue, or mix into a small amount of palatable feed. via dose syringe or add to small amount of palatable feed. Administer twice daily. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

Side Effects

GI: increased motility, diarrhea. Restlessness. QT prolongation risk. Prolonged lactation/galactorrhea. Generally well tolerated at labeled doses in mares.

Precautions

For animals Drug interaction: QT-prolonging drugs — avoid concurrent use. Monitor for adequate prolactin response (mammary development and milk production). Use with caution in pregnant animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Dopamine antagonist — Wash hands thoroughly with soap and water after handling. after handling. Hormonal effects with human exposure. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Overdose

Contact your veterinarian. Domperidone overdose may cause galactorrhea and mild neurological signs.

Equidone Gel 25cc dosage forms

ProductStrengthFormSizeType
EQUIDONE ORAL GEL 110MG/ML 25ML: DOMPERIDONE110 MG/MLGel1Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)