Estradiol Benzoate

Estrogen hormone for uterine receptivity, estrus synchronization, hormone-responsive urinary incontinence, and reproductive therapies. Endogenous estrogen hormone (estradiol 17-beta, benzoate, or cypionate ester). Mechanism: binds intracellular estrogen receptors (ERα and ERβ) → receptor-ligand complex acts as transcription factor → regulates gene expression in reproductive tissues, CNS, bone, liver. Stimulates uterine development and endometrial receptivity; positive feedback on LH release at mid-cycle. Key information Reproductive hormone. Wear gloves — dermal absorption. Refrigerate injectable forms. Store away from children. Do not use in pregnant animals unless specifically indicated. Women of childbearing age should avoid contact.

Injectable (oil-based): administer IM. Warm vial in hands or warm water before drawing up — oil-based solutions inject more easily when warmed. IM injection into large muscle. Store at room temperature; protect from light. If a dose is missed This product is given as a single dose or as part of a defined protocol. Contact your veterinarian if a scheduled administration was missed. Contact your veterinarian.

PU/PD (in spayed dogs). Myelosuppression: bone marrow suppression with high doses (aplastic anemia, pancytopenia — especially estradiol cypionate in dogs; potentially fatal). Pyometra (intact bitches). Behavioral: nymphomania, attractiveness to males. Horses: behavioral changes, mammary development.

For animals Dogs: estradiol cypionate — serious risk of aplastic anemia/pancytopenia at doses used for mismate; avoid where possible. Monitor CBC periodically with prolonged use. Intact females: risk of pyometra and endometrial hyperplasia. Not approved for use in food-producing animals. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Estrogen — wear gloves when handling. Prolonged skin contact may cause hormonal effects. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. (Estrogens are teratogenic/embryotoxic). Keep out of reach of children.

Contact your veterinarian. Estrogen overdose causes bone marrow suppression (aplastic anemia), excessive uterine stimulation, and pyometra risk.