Estrone

Estrogen for estrogen-responsive urinary incontinence in spayed female dogs; reproductive hormone therapy. Endogenous estrogen (estrone). Weaker estrogen than estradiol. Mechanism: binds estrogen receptors (preferentially ERα) → regulates gene transcription in estrogen-responsive tissues. Used for hormone-responsive urinary incontinence in spayed dogs — restores urethral sphincter tone via estrogen receptor-mediated mechanisms. Key information Estrogen hormone. Wear gloves — dermal absorption. Refrigerate injectable. Women of childbearing age should not handle.

Oral: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Administer at consistent times. Store at room temperature; protect from light. If a dose is missed This product is given as a single dose or as part of a defined protocol. Contact your veterinarian if a scheduled administration was missed. Contact your veterinarian for reproductive protocol guidance.

Feminizing effects. Myelosuppression risk (lower than estradiol cypionate). Vulvar swelling. Attractiveness to males. Behavioral changes.

For animals Intact females: risk of pyometra and endometrial hyperplasia with prolonged use. Monitor CBC periodically with prolonged use. Not approved for use in food-producing animals. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Estrogen — wear gloves. Avoid skin contact. Hormonal effects with prolonged exposure. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. Estrogen overdose causes bone marrow suppression and reproductive tract changes.