Estrumate

Cloprostenol (PGF2α analogue) for luteolysis, estrus synchronization, pregnancy termination, and pyometra/luteal cysts in mares and cattle. Synthetic prostaglandin F2α analogue (cloprostenol sodium). Mechanism: binds FP prostaglandin receptors on corpus luteum → luteolysis (corpus luteum regression, progesterone withdrawal). Also stimulates uterine smooth muscle contraction (oxytocic effect). More potent and longer-acting than natural PGF2α. Used for estrus synchronization, luteolysis, and uterine evacuation. Key information Cloprostenol — prostaglandin F2α analogue. HUMAN SAFETY: Bronchospasm risk; do not handle if pregnant or asthmatic. Use protective equipment. Self-injection: emergency — flush immediately, seek medical attention. Wear gloves at all times. Refrigerate.

IM injection (horses and cattle): administer deep IM into large muscle mass. NEVER administer IV. Wear chemical-resistant gloves throughout handling and administration. Dispose of used syringes and vials safely. Store at room temperature; protect from light. Confirm non-pregnant status or intended use before administering. If a dose is missed This product is given as a single dose or as part of a defined protocol. Contact your veterinarian if a scheduled administration was missed. Estrumate is used in reproductive protocols — contact your veterinarian.

GI: abdominal cramping, diarrhea (prostaglandin smooth muscle effects). Sweating, restlessness, tachycardia, bronchospasm (horses — usually transient within 1 hr). Abortion (any pregnant animal — handle carefully). Vasospasm — NEVER inject IV. Human safety: serious cardiovascular and reproductive hazard with skin exposure (especially pregnant women).

For animals Do not administer IV — severe anaphylactoid reactions in horses. Avoid in pregnant animals. — will induce abortion in all pregnant animals. Confirm non-pregnant status or intended use before administration. Monitor horses for bronchospasm and distress for 1 hr post-injection. For people handling this medication SERIOUS HUMAN HAZARD: Cloprostenol is rapidly absorbed through skin and can cause bronchospasm, cardiovascular effects, and serious reproductive harm. Pregnant women and women of childbearing age must NOT handle this product — can induce abortion or premature labor. Wear chemical-resistant (nitrile) gloves and protective clothing. Avoid all skin and eye contact. If skin contact occurs, wash immediately with soap and water. If eye contact occurs, flush with water for 15+ minutes and seek medical attention immediately. If inhaled or ingested, seek emergency medical care. Keep out of reach of children.

Contact your veterinarian. Prostaglandin overdose causes uterine cramping, GI signs, and cardiovascular effects. Human exposure: call Poison Control immediately.