Famotidine

H2-receptor antagonist for gastric and duodenal ulcers, esophagitis, and prevention of NSAID-induced GI ulceration in dogs, cats, and horses. H2 receptor antagonist (famotidine). Mechanism: competitive reversible blockade of histamine H2 receptors on gastric parietal cells → reduces cAMP-mediated activation of proton pump → reduced gastric acid secretion. More potent than cimetidine; fewer drug interactions (minimal CYP450 inhibition). Renally excreted. Key information H2 blocker — less potent than PPIs. Store at room temperature. Fewer drug interactions than cimetidine. IV: dilute and give slowly. Dose reduction in severe renal impairment.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or without. Tablets may be crushed. IV: dilute in 0.9% NaCl; Administer IV slowly; rapid infusion may cause adverse reactions. over 15–30 min. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

Generally well tolerated. GI: constipation or diarrhea (uncommon). CNS: lethargy, dizziness (rare). Thrombocytopenia (rare). Arrhythmias (rare with IV administration). Fewer drug interactions than cimetidine.

For animals Generally safe. Reduce dose or extend interval in renal impairment. — dose-reduce in severe renal failure. May be less effective in horses (short duration; poor oral bioavailability of some formulations). Fewer drug interactions than cimetidine. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). H2 blocker — generally safe. Wash hands thoroughly with soap and water after handling.

Contact your veterinarian. Famotidine overdose causes GI signs and rarely neurological effects at very high doses. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.