Fluconazole Tab

Systemic antifungal (azole) for candidiasis, cryptococcosis, coccidioidomycosis, and other fungal infections; good oral bioavailability and CNS penetration. Triazole antifungal (fluconazole). Mechanism: inhibits fungal CYP51 (lanosterol 14α-demethylase) → blocks ergosterol biosynthesis → disrupts cell membrane integrity and function. Water-soluble; excellent oral bioavailability (>90%); penetrates blood-brain barrier and ocular tissues. Fungistatic. Active against Candida, Cryptococcus, Coccidioides. Key information Store at room temperature. Significant drug interactions (CYP2C9, CYP3A4 inhibitor) — check interactions carefully. Generally well tolerated. Monitor hepatic function with prolonged use. Good CNS penetration. Compounded powder packs: verify stability.

Oral tablets or capsules: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or without. Oral suspension (compounded): Shake well before each use. Store refrigerated (2–8°C); do not freeze. IV (extra-label): infuse at rate ≤200 mg/hr. Store at room temperature; protect from light. (tablets). If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Complete the full antifungal course — antifungal therapy is often prolonged.

GI: nausea, vomiting, diarrhea, anorexia. Hepatotoxicity (elevated liver enzymes — monitor with prolonged use). Skin: rash, pruritus (hypersensitivity). Numerous CYP2C9/CYP3A4 drug interactions (increases cyclosporine, phenytoin, warfarin levels). QT prolongation at high doses.

For animals Monitor liver enzymes with prolonged use. Reduce dose or extend interval in renal impairment. Numerous drug interactions (CYP2C9/CYP3A4 inhibitor): increases cyclosporine, warfarin, phenytoin, benzodiazepine levels. Monitor liver enzymes with prolonged use. Avoid in pregnant animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Triazole antifungal — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Teratogenic at high doses.

Contact your veterinarian. Overdose causes GI signs and liver toxicity. Monitor liver enzymes. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.