Fludrocortisone Acetate

Mineralocorticoid for hypoadrenocorticism (Addison's disease) in dogs; replaces aldosterone. Synthetic mineralocorticoid with glucocorticoid activity (fludrocortisone acetate). Mechanism: potent mineralocorticoid receptor agonist → promotes renal sodium reabsorption and potassium excretion at distal tubule (via aldosterone receptor). ~125× more mineralocorticoid activity than cortisol. Used for aldosterone replacement in Addison's disease. Key information Mineralocorticoid for hypoadrenocorticism. Store at room temperature. Monitor electrolytes and blood pressure. May require concurrent glucocorticoid supplementation especially during stress. Lifelong therapy typically required in Addison's disease.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or without. Administer at consistent times daily. May be split or crushed for dose adjustment. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose.

Sodium/water retention, edema, hypertension. Hypokalemia. PU/PD. Weight gain. With glucocorticoid doses of prednisolone adjunct: typical corticosteroid effects. Monitor electrolytes regularly. Inadequate dose: persistent hyponatremia, hyperkalemia, weakness (Addisonian signs).

For animals Monitor electrolytes (sodium, potassium) every 1–3 months. Adjust dose based on electrolytes and clinical signs — not on ACTH stimulation test. Supplement with oral salt (NaCl) if needed. Monitor blood pressure. Concurrent prednisolone often required for glucocorticoid replacement. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Mineralocorticoid — avoid prolonged skin contact. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. Fludrocortisone overdose causes sodium retention, potassium loss, high blood pressure, and edema. Electrolyte monitoring required.