Fluticasone Propionate

Inhaled corticosteroid for equine asthma (heaves/RAO) and feline asthma; metered-dose inhaler. Inhaled corticosteroid (fluticasone propionate). Mechanism: potent glucocorticoid receptor agonist with high local anti-inflammatory activity (topically active; low systemic bioavailability). Inhibits phospholipase A2 (annexin-1 mediated) → reduces arachidonic acid release → decreased airway prostaglandins and leukotrienes. Lipophilic for prolonged receptor binding. Delivered via MDI. Key information Inhaled corticosteroid. Store at room temperature. Shake well. Use with spacer/mask device in horses. Systemic absorption minimal but possible with high doses. Not for acute bronchospasm.

Inhaled MDI: use appropriate veterinary inhaler device and spacer. Shake inhaler before use. Administer prescribed puffs; hold device in place for 5–10 breaths. Store at room temperature; protect from light. Do not puncture canister. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Inhaled: minimal systemic effects at therapeutic doses. Adrenal suppression with high doses or prolonged use (monitor ACTH stimulation test). Local: oropharyngeal candidiasis (use spacer/rinse face after). Coughing (at time of inhalation). Growth suppression (young animals — high-dose).

For animals Not for acute bronchospasm. Use appropriate equine inhaler device. Monitor for adrenal suppression with prolonged high-dose use. Allow 4–8 weeks to assess full anti-inflammatory effect. For people handling this medication Wash hands thoroughly with soap and water after handling. Inhaled corticosteroid — avoid inhaling aerosol spray. Wash hands after handling inhaler device. Keep out of reach of children.

Contact your veterinarian. Excessive inhalation may cause adrenal suppression. Signs include lethargy, weakness, and loss of appetite.