Galliprant Tabs

Grapiprant (EP4 prostaglandin receptor antagonist) for osteoarthritis pain in dogs; novel mechanism. EP4 prostaglandin receptor antagonist (grapiprant). Mechanism: selectively blocks the EP4 receptor subtype of prostaglandin E2 (PGE2) → interrupts downstream inflammatory and pain signaling without inhibiting COX enzymes. Novel NSAID mechanism: preserves COX-1 and COX-2 prostaglandins (GI protection, platelet function) while blocking EP4-mediated pain and inflammation. Key information Grapiprant — EP4 receptor antagonist NSAID. Dogs only — do not use in cats. Store at room temperature. Administer on empty stomach. Novel MOA — first in class. Do not combine with other NSAIDs.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or on an empty stomach. Administer once daily at consistent time. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

GI: vomiting, diarrhea, soft stools, anorexia (less than non-selective NSAIDs). Renal toxicity with severe dehydration. Hepatotoxicity (rare). Do not use with other NSAIDs or corticosteroids. Generally better GI safety profile than traditional NSAIDs.

For animals Dogs only — not evaluated in cats or horses. Monitor renal function, hydration status, and urine output. Monitor liver enzymes with prolonged use. Do not use concurrently with other NSAIDs or corticosteroids. Use minimum effective dose. Baseline blood work recommended. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). EP4 antagonist NSAID — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children.

Contact your veterinarian immediately. Overdose may cause GI signs (vomiting, diarrhea). Supportive care as needed. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.