Ganciclovir In Lipocream

Antiviral for equine herpesvirus; topical ophthalmic gel for viral keratitis; compounded in lipocream for dermal applications. Nucleoside analogue antiviral (ganciclovir). Mechanism: phosphorylated by viral kinases to active triphosphate form → inhibits viral DNA polymerase and incorporates into viral DNA → chain termination. Active against herpesviruses (EHV, FHV, CMV). Topical ophthalmic gel for viral keratitis; compounded in lipocream for dermal use. Key information Antiviral. Compounded in lipocream for equine ophthalmic use. Store refrigerated. Handle with gloves — potential human reproductive toxicity. Monitor for systemic absorption.

Ophthalmic gel: apply a small amount (approximately 1 cm) into the conjunctival sac 5 times daily. Store refrigerated (2–8°C); do not freeze. Topical cream: apply to lesion with gloved finger. IV (systemic, extra-label): dilute and infuse over 1 hr; wear gloves during preparation. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Ophthalmic gel: local stinging, blurred vision, hypersensitivity (rare). Systemic ganciclovir: myelosuppression (neutropenia, thrombocytopenia), nephrotoxicity, GI upset, CNS effects (seizures, confusion). Topical ophthalmic use minimizes systemic effects.

For animals Topical ophthalmic: minimal systemic exposure — systemic precautions minimal for ophthalmic use. Systemic ganciclovir: Monitor CBC periodically with prolonged use. Monitor renal function, hydration status, and urine output. Avoid in pregnant animals. For people handling this medication Wear gloves when handling. Antiviral — potential carcinogen and teratogen. Wear gloves when handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Do not handle if pregnant. Wash hands thoroughly with soap and water after handling. Keep out of reach of children.

Contact your veterinarian. Compounded ophthalmic ganciclovir — systemic toxicity from topical use is very unlikely.