Omeprazole (Gastrogard)

FDA-approved omeprazole paste for treatment and prevention of equine gastric ulcer syndrome (EGUS); proton pump inhibitor. FDA-approved omeprazole equine paste. Mechanism: irreversible inhibitor of the H+/K+-ATPase proton pump in gastric parietal cells. Prodrug converted to active sulfenamide in acidic canaliculus → covalently binds proton pump → inhibits gastric acid secretion for 24+ hrs. Only FDA-approved treatment for equine gastric ulcer syndrome (EGUS). Key information Omeprazole paste for horses. Store at room temperature. Give on empty stomach or 30–60 minutes before feeding. Shake well. Full 28-day course for active ulcers; 14 days for prevention.

Oral paste (horses): administer via dose syringe on an empty stomach, 30–60 min before feeding. Set dose ring to correct body weight. Press plunger to deposit paste at the back of the tongue. Administer once daily for 28 days for ulcer treatment. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember, on an empty stomach. Do not double up doses.

Generally well tolerated at labeled doses. GI: occasional soft feces, diarrhea. Rebound acid hypersecretion uncommon but possible after prolonged use. Drug interactions: decreased absorption of drugs requiring acidic environment. Masking of ulcer signs should not delay underlying cause treatment.

For animals FDA-approved equine paste — only formulation with established efficacy data in horses. Treat for minimum 28 days for gastric ulcer healing. Confirm diagnosis before prolonged therapy. Drug interaction: reduces absorption of ketoconazole and itraconazole. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Omeprazole paste — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children.

Contact your veterinarian. Omeprazole paste overdose causes GI signs. Rarely serious.