Guanabenz Oral Suspension

Central alpha-2 adrenergic agonist for hypertension; limited veterinary use. Central alpha-2 adrenergic agonist (guanabenz acetate). Mechanism: stimulates alpha-2A adrenoreceptors in brainstem → reduced sympathetic outflow → decreased peripheral vascular resistance and heart rate → antihypertensive effect. Similar to clonidine. Oral administration. Key information Alpha-2 agonist antihypertensive/analgesic. Store at room temperature. May cause sedation and bradycardia. Monitor blood pressure.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Administer at consistent times. Do not abruptly discontinue. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose.

Sedation, lethargy (alpha-2 CNS effect). Dry mouth. Hypotension, bradycardia. Rebound hypertension with abrupt discontinuation. GI: constipation. Respiratory depression at high doses.

For animals Monitor blood pressure and heart rate. Do not abruptly discontinue (rebound hypertension). Use with caution in renal or hepatic impairment. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Alpha-2 agonist antihypertensive — may cause sedation if accidentally ingested. Keep out of reach of children.

Contact your veterinarian. Alpha-2 agonist overdose causes profound sedation and low blood pressure. Reversal with atipamezole may be considered by veterinary staff.