Heartgard Plus 26-50 Lb Chewable Tabs

Ivermectin-based monthly heartworm preventive; Heartgard Plus includes pyrantel for hookworm/roundworm control in dogs. Avermectin antiparasitic (ivermectin ± pyrantel pamoate). Ivermectin mechanism: potentiates GABA-gated chloride channels and glutamate-gated chloride channels in nematodes and arthropods → hyperpolarization → paralysis and death. Pyrantel: nicotinic receptor agonist → depolarizing neuromuscular blockade in nematodes. Monthly oral chewable. Key information Ivermectin/pyrantel. Store at room temperature. Monthly administration — give on same day each month. Administer whole (do not crush). Safe in pregnant/lactating dogs. Avoid in MDR1/ABCB1 mutation dogs (collies) at high doses.

Oral chewable: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or treat. Administer once monthly. Ensure the correct weight-range product is used. Confirm complete ingestion. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. Then continue with the normal monthly schedule. Do not give two doses within a short time span.

Ivermectin component: GI upset (vomiting, diarrhea, anorexia — uncommon at preventive doses). CNS toxicity (ataxia, tremors, coma) in Collie breeds and MDR1-mutant dogs. Pyrantel component: mild GI effects. Generally very well tolerated at monthly preventive doses.

For animals Collies and MDR1/ABCB1-mutant dogs: ivermectin at preventive doses is generally safe but test for MDR1 mutation in at-risk breeds before use. DO NOT use heartworm preventives in dogs with microfilaremia without first treating adult heartworms (risk of anaphylactic-like reaction). Not approved for use in food-producing animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Antiparasitic — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children.

Contact your veterinarian. Heartgard (ivermectin/pyrantel) at the label dose has a very wide safety margin. Large overdose may cause neurological signs — contact vet immediately. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.