Heparin Lock Flush

Anticoagulant for thromboembolic disease; catheter flushing; topical cream for edema/bruising. Anticoagulant glycosaminoglycan (unfractionated heparin / UFH). Mechanism: binds antithrombin III → conformational change in antithrombin III → markedly accelerates inhibition of thrombin (IIa), Factor Xa, IXa, XIa. Short half-life; requires IV CRI or frequent dosing for therapeutic anticoagulation. Topical cream: reduces edema via local anti-inflammatory mechanisms. Key information Anticoagulant. Monitor aPTT. Do not use in animals with active bleeding or thrombocytopenia. Incompatible with many drugs in same solution. Lock flush: heparin-induced thrombocytopenia (HIT) possible (rare in veterinary patients). Antidote: protamine sulfate. Refrigerate.

IV: administer as CRI (therapeutic anticoagulation) or slow IV bolus (flush); dilute in 0.9% NaCl. SQ (UFH): inject SQ — not IM. Heparin flush: instill into IV catheter and flush to maintain patency. Topical cream: apply thin layer to affected area and massage gently. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Hemorrhage (most important adverse effect — monitor for bleeding). Heparin-induced thrombocytopenia (HIT): immune-mediated platelet destruction + paradoxical thrombosis (rare but severe). Hypoaldosteronism (prolonged use → hyperkalemia). Osteoporosis (chronic use). Injection site hematoma.

For animals Monitor for bleeding and thrombocytopenia. HIT (heparin-induced thrombocytopenia): if platelet count drops >50%, discontinue. Monitor aPTT for therapeutic anticoagulation. Antidote: protamine sulfate. Drug interaction: NSAIDs and antiplatelet drugs increase bleeding risk. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Anticoagulant — if accidentally self-injected, seek medical attention. Risk of bleeding. Keep out of reach of children.

Heparin overdose can cause serious bleeding. Contact your veterinarian or emergency clinic immediately. Antidote is protamine sulfate, administered only by veterinary staff. Monitor for signs of bleeding: pale gums, weakness, bloody urine or stool.