Heparin Lock Flush Syringe

Anticoagulant for thromboembolic disease; catheter flushing; topical cream for edema/bruising. Anticoagulant glycosaminoglycan (unfractionated heparin / UFH). Mechanism: binds antithrombin III → conformational change in antithrombin III → markedly accelerates inhibition of thrombin (IIa), Factor Xa, IXa, XIa. Short half-life; requires IV CRI or frequent dosing for therapeutic anticoagulation. Topical cream: reduces edema via local anti-inflammatory mechanisms.

IV: administer as CRI (therapeutic anticoagulation) or slow IV bolus (flush); dilute in 0.9% NaCl. SQ (UFH): inject SQ — not IM. Heparin flush: instill into IV catheter and flush to maintain patency. Topical cream: apply thin layer to affected area and massage gently. Store at room temperature; protect from light.

Hemorrhage (most important adverse effect — monitor for bleeding). Heparin-induced thrombocytopenia (HIT): immune-mediated platelet destruction + paradoxical thrombosis (rare but severe). Hypoaldosteronism (prolonged use → hyperkalemia). Osteoporosis (chronic use). Injection site hematoma.

For animals Monitor for bleeding and thrombocytopenia. HIT (heparin-induced thrombocytopenia): if platelet count drops >50%, discontinue. Monitor aPTT for therapeutic anticoagulation. Antidote: protamine sulfate. Drug interaction: NSAIDs and antiplatelet drugs increase bleeding risk. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Anticoagulant — if accidentally self-injected, seek medical attention. Risk of bleeding. Keep out of reach of children.