Hydroxyzine Hcl

Antihistamine with anxiolytic properties for pruritus, urticaria, and anxiety in dogs; atopic dermatitis adjunct. First-generation H1 antihistamine with anxiolytic properties (hydroxyzine HCl). Mechanism: competitive antagonist at peripheral and central H1 histamine receptors; also anticholinergic and serotonin 5-HT2 antagonist properties. Anxiolytic effect via histamine receptor blockade in the limbic system. CNS sedation at therapeutic doses. Hepatically metabolized to cetirizine (active metabolite). Key information Antihistamine. Sedation common — advise clients. Safe for long-term use. Administer with food to reduce GI upset. QT prolongation at high doses. Store at room temperature.

Oral tablets or capsules: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Tablets may be crushed. Injectable (HCl form): IM only — do not give SQ or IV. Administer 2–3 times daily as directed. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

CNS sedation (common — H1 and anticholinergic). Anticholinergic effects: dry mouth, urinary retention, GI hypomotility. GI: vomiting (uncommon). Tachycardia. Avoid in horses — may cause CNS excitability/agitation.

For animals Avoid in horses — CNS excitability (paradoxical reaction) reported. Use with caution in patients with glaucoma or urinary obstruction (anticholinergic effects). Use with caution in hepatic impairment. CNS depressant — avoid concurrent sedatives. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Antihistamine — may cause drowsiness if accidentally ingested. Keep out of reach of children.

Contact your veterinarian. Hydroxyzine overdose causes excessive sedation and anticholinergic signs. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.