Imipramine Hcl Tab

Tricyclic antidepressant for narcolepsy and cataplexy in horses; urinary incontinence in dogs; behavioral disorders. Tricyclic antidepressant. Mechanism: serotonin and norepinephrine reuptake inhibitor; anticholinergic and antihistaminic properties. Increases urethral sphincter tone via alpha-1 adrenergic effects in dogs. In horses: modulates sleep/wake cycle via catecholaminergic pathways for narcolepsy management. Key information Tricyclic antidepressant. Narrow therapeutic index. Cardiac toxicity at high doses — do not exceed recommended doses. Drug interactions: MAOIs (do not combine). Store at room temperature.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Tablets may be crushed and mixed into food. Administer at consistent times. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose.

Anticholinergic: dry mouth, urinary retention, constipation, ileus. Cardiovascular: tachycardia, AV block, arrhythmias. CNS: lowered seizure threshold, sedation. Serotonin syndrome (MAOIs).

For animals Avoid concurrent MAOIs. Lowers seizure threshold. Use with caution in hepatic impairment. Monitor for urinary retention and cardiac arrhythmias. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Tricyclic — very dangerous to children if ingested (arrhythmias, seizures). Store securely. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian or emergency clinic immediately. TCA overdose causes serious cardiac arrhythmias, seizures, and low blood pressure. This is a medical emergency. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.