Incurin Tabs

Estriol for treatment of estrogen-responsive urinary incontinence in spayed female dogs. Estriol (short-acting synthetic estrogen). Mechanism: binds estrogen receptors in urethral sphincter smooth muscle and submucosal tissue → increases urethral closure pressure and sphincter tone. Estriol preferentially binds ERβ in urinary tract. Short duration of action requires regular dosing. Minimal systemic estrogenic effects compared to estradiol. Key information Estriol — estrogen for urinary incontinence in spayed female dogs. Store at room temperature. Dogs only. Monitor for signs of estrogen excess (swollen vulva, attracting males).

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or without. Administer once daily. Tablets may be split for dose adjustment. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

GI: vomiting (transient). Vulvar enlargement, attractiveness to male dogs. Myelosuppression risk is lower than with estradiol cypionate but bone marrow effects possible with prolonged use (monitor CBC). Estrogen-responsive neoplasms: avoid in intact or estrogen-responsive tumor animals.

For animals Spayed dogs only — do not use in intact females (pyometra risk). Monitor CBC periodically with prolonged use. Monitor for estrogen-responsive tumors. Drug interaction: no significant interactions documented at estriol doses. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Estriol — wear gloves. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Hormonal drug — women should minimize exposure.

Contact your veterinarian. Estriol overdose causes signs of estrogen excess: swollen vulva and attracting males. Bone marrow effects with large overdose.